"Sublingual administration of drugs is a modern direction of medicine. This method of administering drugs into the body allows you to avoid the negative impact of drugs on the gastric mucosa, accelerates the absorption of active substances into the bloodstream - directly through the mucous membrane of the oral cavity. Our drugs in sublingual form have the property of being absorbed directly through the mucous membrane of the oral cavity, which contributes to faster penetration of peptides. This leads to an acceleration of the drug effect. In addition, when using several drugs at the same time, the sublingual method of administering drugs allows you to avoid the need to swallow a large number of gelatin capsules, which may be undesirable in case of stomach problems, for example, chronic gastritis or gastric ulcer and duodenal ulcer.
The dosages of the drugs for sublingual use are the same as in capsules: 1 ml of the solution for sublingual use contains 10 mg of the active substance for cytomaxes or 100 mcg for cytogens - the same as in 1 capsule. It is recommended to use the drugs in the amount of 1 ml of solution per day - 3-4 drops 2-3 times a day approximately. As a result, the daily dosage is less than in capsules: capsules are taken twice a day at 10 mg (or 100 mcg for cytogens), and in the case of linguals, the same dosage (10 mg) is taken per day. But at the same time, a similar effect is obtained, since the absorption of peptides occurs immediately, directly in the oral cavity. "
Galina Ryzhak,
medical consultant Peptides
In terms of permeability, the sublingual region of the oral cavity is more permeable than the buccal region, which, in turn, is superior to the palatine region. Differences in permeability are due to differences in the thickness and blood supply of these membranes. The bioavailability of drugs when administered sublingually also depends on the physicochemical properties of the substances, so not all drugs may be suitable for transport through the oral mucosa due to the peculiarities of its structure and the physicochemical nature of the drug. The effectiveness of sublingual drugs is associated with the structure of the sublingual zone, which is highly vascularized. Drugs directly enter the pulmonary circulation, bypassing the portal vein, bypassing metabolism and processing in the liver. Penetration of drugs is carried out by passive diffusion through lipid membranes and per unit of time exceeds the rate of oral administration by 3-10 times, second only to subcutaneous injections. Sublingual preparations have been developed for numerous indications where rapid onset of action is important, from migraines to cardiovascular diseases. They are also indicated for use in people with gastrointestinal diseases.
Let's consider the advantages of the sublingual form of drug administration. This route of administration is most optimal for the use of highly active substances in low concentrations, which include peptides.
The sublingual form of peptide preparations is already well known to our consumers through the Revilab SL line – the first in the world practice series of multicomponent preparations for sublingual use, created by our company for the prevention of diseases and correction of various conditions.
The most important advantage of the new bioregulators is the ability to smoothly and individually adjust the dosage. The key point is that the body is involved in the recovery process quickly, but at the same time gently and smoothly. In addition, since the preparation is liquid and is dosed drop by drop, it is very easy to select the dosage of the bioregulator suitable for each individual.
WHO ARE SUBLINGUAL PEPTIDE DRUGS ADDRESSED TO?
First of all, people over 50 years old. We must take into account their hypersensitivity to parapharmaceuticals. It must be remembered that for people over 50 years old, taking any medication requires caution and a thoughtful approach. Over the years, our body undergoes various changes due to aging. The number of healthy and functionally active cells in the body decreases, they are replaced by proliferating connective tissue (fibrosis). With age, the amount of water in the body as a percentage decreases. An infant's body consists of almost 90% water. But in old age, only about 40% of water remains in the body. Body weight increases, but the amount of water in tissues and cells decreases. Because of this, metabolism is disrupted, which largely affects the decrease in the effectiveness of drugs in capsules.
The changes also affect the vascular bed. The trophism of capillary cells is disrupted, some of them gradually become empty and areas of hypoxia in the tissues appear. The level of cholesterol in the blood increases, it settles on the walls of the arteries and further worsens blood circulation. As a result, the supply of oxygen and nutrients to organs and tissues and the removal of waste products of metabolism from them are disrupted. Such important organs as the kidneys, lungs and liver also undergo changes at the cellular level with age. They already perform their basic functions worse: the liver cannot cope with the processing, and the lungs and kidneys with the removal of harmful, toxic decay products. All these nuances are not taken into account when developing drugs for people over 50 years old, and drug developers do not always consider it necessary to take old age into account, therefore, there are many more side effects from taking various drugs in older people.
When using linguals, we get a general response from the body in the form of normalization of the function of the corresponding organs and tissues. Small concentrations of the active substance in sublingual preparations serve as a guarantee against hyperactivation of regulatory systems, since in old age the body's reserves for bioregulation are no longer large and should not be overstrained. So, it is the reduced dosage that gives us the desired effect. Thus, due to the speed of action, sufficient efficiency, ease of use, sublingual preparations have gained particular popularity. Their development is justified by high biological availability, ease of use, and indispensability in many cases of clinical practice.
